Peptic Ulcer Disease

Body Systems › Gastrointestinal System › Peptic Ulcer Disease
GI Clinical reference

Peptic Ulcer Disease

PUD: ulceration of gastric or duodenal mucosa from H. pylori (most common), NSAIDs, or stress (ICU). H. pylori eradication with triple therapy is curative. PPIs provide symptom relief.

PUD peptic ulcer gastric ulcer duodenal ulcer H. pylori ulcer
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Evidence
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Trials
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Latest evidence

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Core official overview

What this condition is

A peptic ulcer is a sore in the lining of your stomach or your duodenum, the first part of your small intestine. A burning stomach pain is the most common symptom. The pain:Starts between meals or during the nightBriefly stops if you eat or take antacidsLasts for minutes to hoursComes and goes for several days or weeksPeptic ulcers happen when the acids that help you digest food damage the walls of the stomach or du…

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Common tests

Tests performed

EGD (gold standard) H. pylori: Urea breath test or Fecal antigen (preferred) Serology (past exposure only) CBC BMP Fasting gastrin (Zollinger-Ellison concern)
Common medications

Recognize the drug and the class

H. pylori: Triple therapy — PPI + Clarithromycin + Amoxicillin × 14d Bismuth quadruple therapy (clarithromycin resistance) PPI (omeprazole, pantoprazole) × 4-8 weeks Misoprostol (NSAID prophylaxis) Discontinue NSAIDs
Related nursing diagnoses

NANDA diagnoses & care plans

Use these direct links to open nursing diagnoses and care-plan support related to Peptic Ulcer Disease.

Acute Pain Deficient Knowledge Non-Compliance Risk for GI Bleeding
Recruiting clinical trials

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Plain-language study support

Useful for plain-language reinforcement and quick review.

Peptic Ulcer A peptic ulcer is a sore in the lining of your stomach or your duodenum, the first part of your small intestine. A burning stomach pain is the most common symptom. The pain:Starts between meals or during the nightBriefly stops if you eat or take antacidsLasts for minutes to hoursComes and goes for several days or weeksPeptic ulcers happen when the acids that help you digest food damage the walls of the stomach or du… Helicobacter pylori Infections Helicobacter pylori (H. pylori) is a type of bacteria that causes infection in the stomach. It is the main cause of peptic ulcers, and it can also cause gastritis and stomach cancer.About 30 to 40% of people in the United States get an H. pylori infection. Most people get it as a child. H. pylori usually does not cause symptoms. But it can break down the inner protective coating in some people's stomachs and cause i… Small Intestine Disorders Your small intestine is the longest part of your digestive system - about twenty feet long! It connects your stomach to your large intestine (or colon) and folds many times to fit inside your abdomen. Your small intestine does most of the digesting of the foods you eat. It has three areas called the duodenum, the ileum, and the jejunum.Problems with the small intestine can include:BleedingCeliac diseaseCrohn's disea… Gastrointestinal Bleeding Your digestive or gastrointestinal (GI) tract includes the esophagus, stomach, small intestine, large intestine or colon, rectum, and anus. Bleeding can come from any of these areas. The amount of bleeding can be so small that only a lab test can find it. Signs of bleeding in the digestive tract depend on where it is and how much bleeding there is.Signs of bleeding in the upper digestive tract include:Bright red blo…