Error message
User warning: mkdir(): Permission Denied in Drupal\Component\PhpStorage\FileStorage->createDirectory() (line 125 of core/lib/Drupal/Component/PhpStorage/FileStorage.php).
Drupal\Component\PhpStorage\FileStorage->createDirectory() (Line: 73) Drupal\Component\PhpStorage\FileStorage->ensureDirectory() (Line: 66) Drupal\Component\PhpStorage\MTimeProtectedFastFileStorage->save() (Line: 116) Drupal\Core\Template\TwigPhpStorageCache->write() (Line: 410) Twig\Environment->loadTemplate() (Line: 370) Twig\Environment->load() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 242) Drupal\Core\Render\MainContent\HtmlRenderer->{closure:Drupal\Core\Render\MainContent\HtmlRenderer::prepare():235}() (Line: 634) Drupal\Core\Render\Renderer::{closure:Drupal\Core\Render\Renderer::executeInRenderContext():634}() Fiber->start() (Line: 635) Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 235) Drupal\Core\Render\MainContent\HtmlRenderer->prepare() (Line: 131) Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90) Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray() (Line: 246) Symfony\Component\EventDispatcher\EventDispatcher::{closure:Symfony\Component\EventDispatcher\EventDispatcher::optimizeListeners():241}() (Line: 206) Symfony\Component\EventDispatcher\EventDispatcher->callListeners() (Line: 56) Symfony\Component\EventDispatcher\EventDispatcher->dispatch() (Line: 188) Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76) Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53) Drupal\Core\StackMiddleware\Session->handle() (Line: 48) Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28) Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32) Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 203) Drupal\page_cache\StackMiddleware\PageCache->fetch() (Line: 140) Drupal\page_cache\StackMiddleware\PageCache->lookup() (Line: 89) Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 48) Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51) Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 53) Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 54) Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 745) Drupal\Core\DrupalKernel->handle() (Line: 19)User warning: mkdir(): Permission Denied in Drupal\Component\PhpStorage\FileStorage->createDirectory() (line 125 of core/lib/Drupal/Component/PhpStorage/FileStorage.php).
Drupal\Component\PhpStorage\FileStorage->createDirectory() (Line: 73) Drupal\Component\PhpStorage\FileStorage->ensureDirectory() (Line: 66) Drupal\Component\PhpStorage\MTimeProtectedFastFileStorage->save() (Line: 116) Drupal\Core\Template\TwigPhpStorageCache->write() (Line: 410) Twig\Environment->loadTemplate() (Line: 370) Twig\Environment->load() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 162) Drupal\Core\Render\MainContent\HtmlRenderer->{closure:Drupal\Core\Render\MainContent\HtmlRenderer::renderResponse():157}() (Line: 634) Drupal\Core\Render\Renderer::{closure:Drupal\Core\Render\Renderer::executeInRenderContext():634}() Fiber->start() (Line: 635) Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 157) Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90) Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray() (Line: 246) Symfony\Component\EventDispatcher\EventDispatcher::{closure:Symfony\Component\EventDispatcher\EventDispatcher::optimizeListeners():241}() (Line: 206) Symfony\Component\EventDispatcher\EventDispatcher->callListeners() (Line: 56) Symfony\Component\EventDispatcher\EventDispatcher->dispatch() (Line: 188) Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76) Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53) Drupal\Core\StackMiddleware\Session->handle() (Line: 48) Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28) Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32) Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 203) Drupal\page_cache\StackMiddleware\PageCache->fetch() (Line: 140) Drupal\page_cache\StackMiddleware\PageCache->lookup() (Line: 89) Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 48) Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51) Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 53) Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 54) Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 745) Drupal\Core\DrupalKernel->handle() (Line: 19)User warning: mkdir(): Permission Denied in Drupal\Component\PhpStorage\FileStorage->createDirectory() (line 125 of core/lib/Drupal/Component/PhpStorage/FileStorage.php).
Drupal\Component\PhpStorage\FileStorage->createDirectory() (Line: 73) Drupal\Component\PhpStorage\FileStorage->ensureDirectory() (Line: 66) Drupal\Component\PhpStorage\MTimeProtectedFastFileStorage->save() (Line: 116) Drupal\Core\Template\TwigPhpStorageCache->write() (Line: 410) Twig\Environment->loadTemplate() (Line: 370) Twig\Environment->load() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 501) Drupal\Core\Template\TwigExtension->escapeFilter() (Line: 96) __TwigTemplate_1542e28ecd23eb9f51b3cf19a0f0d78b->doDisplay() (Line: 402) Twig\Template->yield() (Line: 386) Twig\Template->render() (Line: 51) Twig\TemplateWrapper->render() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 162) Drupal\Core\Render\MainContent\HtmlRenderer->{closure:Drupal\Core\Render\MainContent\HtmlRenderer::renderResponse():157}() (Line: 634) Drupal\Core\Render\Renderer::{closure:Drupal\Core\Render\Renderer::executeInRenderContext():634}() Fiber->start() (Line: 635) Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 157) Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90) Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray() (Line: 246) Symfony\Component\EventDispatcher\EventDispatcher::{closure:Symfony\Component\EventDispatcher\EventDispatcher::optimizeListeners():241}() (Line: 206) Symfony\Component\EventDispatcher\EventDispatcher->callListeners() (Line: 56) Symfony\Component\EventDispatcher\EventDispatcher->dispatch() (Line: 188) Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76) Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53) Drupal\Core\StackMiddleware\Session->handle() (Line: 48) Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28) Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32) Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 203) Drupal\page_cache\StackMiddleware\PageCache->fetch() (Line: 140) Drupal\page_cache\StackMiddleware\PageCache->lookup() (Line: 89) Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 48) Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51) Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 53) Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 54) Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 745) Drupal\Core\DrupalKernel->handle() (Line: 19)User warning: mkdir(): Permission Denied in Drupal\Component\PhpStorage\FileStorage->createDirectory() (line 125 of core/lib/Drupal/Component/PhpStorage/FileStorage.php).
Drupal\Component\PhpStorage\FileStorage->createDirectory() (Line: 73) Drupal\Component\PhpStorage\FileStorage->ensureDirectory() (Line: 66) Drupal\Component\PhpStorage\MTimeProtectedFastFileStorage->save() (Line: 116) Drupal\Core\Template\TwigPhpStorageCache->write() (Line: 410) Twig\Environment->loadTemplate() (Line: 370) Twig\Environment->load() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 556) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 501) Drupal\Core\Template\TwigExtension->escapeFilter() (Line: 77) __TwigTemplate_71870a835705e73bfa6156daf8f36212->doDisplay() (Line: 402) Twig\Template->yield() (Line: 386) Twig\Template->render() (Line: 51) Twig\TemplateWrapper->render() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 501) Drupal\Core\Template\TwigExtension->escapeFilter() (Line: 96) __TwigTemplate_1542e28ecd23eb9f51b3cf19a0f0d78b->doDisplay() (Line: 402) Twig\Template->yield() (Line: 386) Twig\Template->render() (Line: 51) Twig\TemplateWrapper->render() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 162) Drupal\Core\Render\MainContent\HtmlRenderer->{closure:Drupal\Core\Render\MainContent\HtmlRenderer::renderResponse():157}() (Line: 634) Drupal\Core\Render\Renderer::{closure:Drupal\Core\Render\Renderer::executeInRenderContext():634}() Fiber->start() (Line: 635) Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 157) Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90) Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray() (Line: 246) Symfony\Component\EventDispatcher\EventDispatcher::{closure:Symfony\Component\EventDispatcher\EventDispatcher::optimizeListeners():241}() (Line: 206) Symfony\Component\EventDispatcher\EventDispatcher->callListeners() (Line: 56) Symfony\Component\EventDispatcher\EventDispatcher->dispatch() (Line: 188) Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76) Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53) Drupal\Core\StackMiddleware\Session->handle() (Line: 48) Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28) Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32) Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 203) Drupal\page_cache\StackMiddleware\PageCache->fetch() (Line: 140) Drupal\page_cache\StackMiddleware\PageCache->lookup() (Line: 89) Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 48) Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51) Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 53) Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 54) Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 745) Drupal\Core\DrupalKernel->handle() (Line: 19)User warning: mkdir(): Permission Denied in Drupal\Component\PhpStorage\FileStorage->createDirectory() (line 125 of core/lib/Drupal/Component/PhpStorage/FileStorage.php).
Drupal\Component\PhpStorage\FileStorage->createDirectory() (Line: 73) Drupal\Component\PhpStorage\FileStorage->ensureDirectory() (Line: 66) Drupal\Component\PhpStorage\MTimeProtectedFastFileStorage->save() (Line: 116) Drupal\Core\Template\TwigPhpStorageCache->write() (Line: 410) Twig\Environment->loadTemplate() (Line: 370) Twig\Environment->load() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 513) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 501) Drupal\Core\Template\TwigExtension->escapeFilter() (Line: 166) __TwigTemplate_71870a835705e73bfa6156daf8f36212->doDisplay() (Line: 402) Twig\Template->yield() (Line: 386) Twig\Template->render() (Line: 51) Twig\TemplateWrapper->render() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 501) Drupal\Core\Template\TwigExtension->escapeFilter() (Line: 96) __TwigTemplate_1542e28ecd23eb9f51b3cf19a0f0d78b->doDisplay() (Line: 402) Twig\Template->yield() (Line: 386) Twig\Template->render() (Line: 51) Twig\TemplateWrapper->render() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 162) Drupal\Core\Render\MainContent\HtmlRenderer->{closure:Drupal\Core\Render\MainContent\HtmlRenderer::renderResponse():157}() (Line: 634) Drupal\Core\Render\Renderer::{closure:Drupal\Core\Render\Renderer::executeInRenderContext():634}() Fiber->start() (Line: 635) Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 157) Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90) Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray() (Line: 246) Symfony\Component\EventDispatcher\EventDispatcher::{closure:Symfony\Component\EventDispatcher\EventDispatcher::optimizeListeners():241}() (Line: 206) Symfony\Component\EventDispatcher\EventDispatcher->callListeners() (Line: 56) Symfony\Component\EventDispatcher\EventDispatcher->dispatch() (Line: 188) Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76) Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53) Drupal\Core\StackMiddleware\Session->handle() (Line: 48) Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28) Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32) Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 203) Drupal\page_cache\StackMiddleware\PageCache->fetch() (Line: 140) Drupal\page_cache\StackMiddleware\PageCache->lookup() (Line: 89) Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 48) Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51) Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 53) Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 54) Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 745) Drupal\Core\DrupalKernel->handle() (Line: 19)User warning: mkdir(): Permission Denied in Drupal\Component\PhpStorage\FileStorage->createDirectory() (line 125 of core/lib/Drupal/Component/PhpStorage/FileStorage.php).
Drupal\Component\PhpStorage\FileStorage->createDirectory() (Line: 73) Drupal\Component\PhpStorage\FileStorage->ensureDirectory() (Line: 66) Drupal\Component\PhpStorage\MTimeProtectedFastFileStorage->save() (Line: 116) Drupal\Core\Template\TwigPhpStorageCache->write() (Line: 410) Twig\Environment->loadTemplate() (Line: 370) Twig\Environment->load() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 501) Drupal\Core\Template\TwigExtension->escapeFilter() (Line: 139) __TwigTemplate_033accae3f1ee663fc609d06659d9dce->block_content() (Line: 446) Twig\Template->yieldBlock() (Line: 115) __TwigTemplate_033accae3f1ee663fc609d06659d9dce->doDisplay() (Line: 402) Twig\Template->yield() (Line: 386) Twig\Template->render() (Line: 51) Twig\TemplateWrapper->render() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 513) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 501) Drupal\Core\Template\TwigExtension->escapeFilter() (Line: 166) __TwigTemplate_71870a835705e73bfa6156daf8f36212->doDisplay() (Line: 402) Twig\Template->yield() (Line: 386) Twig\Template->render() (Line: 51) Twig\TemplateWrapper->render() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 501) Drupal\Core\Template\TwigExtension->escapeFilter() (Line: 96) __TwigTemplate_1542e28ecd23eb9f51b3cf19a0f0d78b->doDisplay() (Line: 402) Twig\Template->yield() (Line: 386) Twig\Template->render() (Line: 51) Twig\TemplateWrapper->render() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 162) Drupal\Core\Render\MainContent\HtmlRenderer->{closure:Drupal\Core\Render\MainContent\HtmlRenderer::renderResponse():157}() (Line: 634) Drupal\Core\Render\Renderer::{closure:Drupal\Core\Render\Renderer::executeInRenderContext():634}() Fiber->start() (Line: 635) Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 157) Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90) Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray() (Line: 246) Symfony\Component\EventDispatcher\EventDispatcher::{closure:Symfony\Component\EventDispatcher\EventDispatcher::optimizeListeners():241}() (Line: 206) Symfony\Component\EventDispatcher\EventDispatcher->callListeners() (Line: 56) Symfony\Component\EventDispatcher\EventDispatcher->dispatch() (Line: 188) Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76) Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53) Drupal\Core\StackMiddleware\Session->handle() (Line: 48) Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28) Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32) Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 203) Drupal\page_cache\StackMiddleware\PageCache->fetch() (Line: 140) Drupal\page_cache\StackMiddleware\PageCache->lookup() (Line: 89) Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 48) Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51) Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 53) Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 54) Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 745) Drupal\Core\DrupalKernel->handle() (Line: 19)User warning: mkdir(): Permission Denied in Drupal\Component\PhpStorage\FileStorage->createDirectory() (line 125 of core/lib/Drupal/Component/PhpStorage/FileStorage.php).
Drupal\Component\PhpStorage\FileStorage->createDirectory() (Line: 73) Drupal\Component\PhpStorage\FileStorage->ensureDirectory() (Line: 66) Drupal\Component\PhpStorage\MTimeProtectedFastFileStorage->save() (Line: 116) Drupal\Core\Template\TwigPhpStorageCache->write() (Line: 410) Twig\Environment->loadTemplate() (Line: 370) Twig\Environment->load() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 556) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 501) Drupal\Core\Template\TwigExtension->escapeFilter() (Line: 96) __TwigTemplate_1542e28ecd23eb9f51b3cf19a0f0d78b->doDisplay() (Line: 402) Twig\Template->yield() (Line: 386) Twig\Template->render() (Line: 51) Twig\TemplateWrapper->render() (Line: 35) Drupal\Core\Template\TwigThemeEngine->renderTemplate() (Line: 428) Drupal\Core\Theme\ThemeManager->render() (Line: 500) Drupal\Core\Render\Renderer->doRender() (Line: 230) Drupal\Core\Render\Renderer->render() (Line: 162) Drupal\Core\Render\MainContent\HtmlRenderer->{closure:Drupal\Core\Render\MainContent\HtmlRenderer::renderResponse():157}() (Line: 634) Drupal\Core\Render\Renderer::{closure:Drupal\Core\Render\Renderer::executeInRenderContext():634}() Fiber->start() (Line: 635) Drupal\Core\Render\Renderer->executeInRenderContext() (Line: 157) Drupal\Core\Render\MainContent\HtmlRenderer->renderResponse() (Line: 90) Drupal\Core\EventSubscriber\MainContentViewSubscriber->onViewRenderArray() (Line: 246) Symfony\Component\EventDispatcher\EventDispatcher::{closure:Symfony\Component\EventDispatcher\EventDispatcher::optimizeListeners():241}() (Line: 206) Symfony\Component\EventDispatcher\EventDispatcher->callListeners() (Line: 56) Symfony\Component\EventDispatcher\EventDispatcher->dispatch() (Line: 188) Symfony\Component\HttpKernel\HttpKernel->handleRaw() (Line: 76) Symfony\Component\HttpKernel\HttpKernel->handle() (Line: 53) Drupal\Core\StackMiddleware\Session->handle() (Line: 48) Drupal\Core\StackMiddleware\KernelPreHandle->handle() (Line: 28) Drupal\Core\StackMiddleware\ContentLength->handle() (Line: 32) Drupal\big_pipe\StackMiddleware\ContentLength->handle() (Line: 203) Drupal\page_cache\StackMiddleware\PageCache->fetch() (Line: 140) Drupal\page_cache\StackMiddleware\PageCache->lookup() (Line: 89) Drupal\page_cache\StackMiddleware\PageCache->handle() (Line: 48) Drupal\Core\StackMiddleware\ReverseProxyMiddleware->handle() (Line: 51) Drupal\Core\StackMiddleware\NegotiationMiddleware->handle() (Line: 53) Drupal\Core\StackMiddleware\AjaxPageState->handle() (Line: 54) Drupal\Core\StackMiddleware\StackedHttpKernel->handle() (Line: 745) Drupal\Core\DrupalKernel->handle() (Line: 19)
Hematology / Blood System
Hematology overview
Hematology / Blood System
Blood and coagulation conditions, evidence, coding, and nursing diagnoses.
Conditions
Major hematology conditions
Select a condition
Hematology
6 sections
Anemia
Anemia: Hgb <13.5 g/dL (men) or <12 g/dL (women). Classified by MCV: microcytic (iron deficiency), normocytic (chronic disease, AKI, blood loss), macrocytic (B12/folate). Identify and treat cause.
anemia
anaemia
low hemoglobin
Overview
ICD-10
Evidence
Trials
Tests Meds
Open condition →
Hematology
6 sections
SCD
SCD: hemoglobin S polymerization causing RBC sickling, hemolytic anemia, vaso-occlusion, and organ damage. Hydroxyurea reduces crises. Voxelotor and crizanlizumab are newer agents.
sickle cell disease
SCD
sickle cell anemia
Overview
ICD-10
Evidence
Trials
Tests Meds
Open condition →
Hematology
6 sections
VOC
Vaso-occlusive crisis (VOC): severe pain from ischemia in bones, chest, abdomen. Acute chest syndrome (ACS) — infiltrate + chest pain/fever — is life-threatening. Analgesia within 30 minutes.
VOC
vaso-occlusive crisis
sickle cell pain crisis
Overview
ICD-10
Evidence
Trials
Tests Meds
Open condition →
Hematology
6 sections
Low Platelets
Thrombocytopenia: platelet count <150,000. Causes: ITP (immune), HIT, TTP, DIC, drug-induced, liver disease, bone marrow failure. Spontaneous bleeding risk when platelets <20,000.
thrombocytopenia
low platelets
ITP
Overview
ICD-10
Evidence
Trials
Tests Meds
Open condition →
Hematology
6 sections
HIT
HIT is antibody-mediated platelet activation by heparin-PF4 complexes causing paradoxical thrombosis. Platelet drop ≥50% 5-14 days after heparin. Stop ALL heparin immediately — use alternative anticoagulant.
HIT
heparin-induced thrombocytopenia
HITT
Overview
ICD-10
Evidence
Trials
Tests Meds
Open condition →
Hematology
6 sections
DIC
DIC is pathologic systemic activation of coagulation causing simultaneous clotting and bleeding. Triggers: sepsis, trauma, obstetric emergencies, malignancy. Treat underlying cause + supportive.
DIC
disseminated intravascular coagulation
consumption coagulopathy
Overview
ICD-10
Evidence
Trials
Tests Meds
Open condition →
Hematology
6 sections
Anticoagulation
Anticoagulation therapy for VTE prevention, AF stroke prophylaxis, and mechanical valves. DOACs (direct oral anticoagulants) have largely replaced warfarin. Reversal agents are available for all major DOACs.
anticoagulation
blood thinners
warfarin
Overview
ICD-10
Evidence
Trials
Tests Meds
Open condition →
Hematology
6 sections
Febrile Neutropenia
Neutropenia: ANC <1500. Febrile neutropenia: ANC <500 + temperature ≥38.3°C — oncologic emergency requiring broad-spectrum antibiotics within 1 hour. MASCC score guides inpatient vs outpatient.
febrile neutropenia
neutropenia
FN
Overview
ICD-10
Evidence
Trials
Tests Meds
Open condition →
Nursing diagnoses & care plans
Related nursing diagnoses
Related tool
NANDA
Care plans
Nursing Diagnoses & Care Plans
Open the NANDA tool to review nursing diagnoses and care-plan concepts related to hematology conditions.
Open NANDA tool →