NAFLD / NASH

Body Systems › Hepatic / Biliary System › NAFLD / NASH
Liver/Biliary Clinical reference

NAFLD / NASH

NAFLD: fat in liver without significant alcohol use. NASH (nonalcoholic steatohepatitis): NAFLD + inflammation/fibrosis. Leading cause of cirrhosis worldwide. Resmetirom FDA-approved 2024 for MASH.

NAFLD NASH MAFLD MASH fatty liver nonalcoholic fatty liver disease metabolic-associated steatotic liver disease
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Core official overview

What this condition is

What is steatotic liver disease?Your liver is the largest organ inside your body. It helps you digest food, store energy, and remove harmful substances (toxins). Steatotic liver disease, formerly called fatty liver disease, happens when too much fat builds up in your liver. It's typical to have some fat in your liver cells, but too much can be a problem.There are two main types of steatotic liver disease:Metabolic d…

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Common tests

Tests performed

LFTs (elevated ALT/AST — AST:ALT ratio <1 in NAFLD) Fibroscan or FIB-4 score MRI-PDFF (fat quantification) Liver biopsy (staging — gold standard) HbA1c Lipid panel BMI + waist circumference
Common medications

Recognize the drug and the class

Lifestyle modification (weight loss 7-10% — reduces fibrosis) Resmetirom (Rezdiffra) — FDA approved March 2024 (MASH F2-F3) Semaglutide (GLP-1 — investigational for NASH) Pioglitazone (NASH with T2DM) Vitamin E 800 IU (non-diabetic NASH — moderate evidence)
Related nursing diagnoses

NANDA diagnoses & care plans

Use these direct links to open nursing diagnoses and care-plan support related to NAFLD / NASH.

Imbalanced Nutrition Ineffective Health Maintenance Activity Intolerance Deficient Knowledge
Official education links

Plain-language study support

Useful for plain-language reinforcement and quick review.

Steatotic Liver Disease What is steatotic liver disease?Your liver is the largest organ inside your body. It helps you digest food, store energy, and remove harmful substances (toxins). Steatotic liver disease, formerly called fatty liver disease, happens when too much fat builds up in your liver. It's typical to have some fat in your liver cells, but too much can be a problem.There are two main types of steatotic liver disease:Metabolic d… Cirrhosis Cirrhosis is scarring of the liver. Scar tissue forms because of injury or long-term disease. Scar tissue cannot do what healthy liver tissue does - make protein, help fight infections, clean the blood, help digest food and store energy. Cirrhosis can lead to :Easy bruising or bleeding, or nosebleedsSwelling of the abdomen or legs Extra sensitivity to medicinesHigh blood pressure in the vein entering the liverEnlarg…